Beyond Tragedy: Structure and Experience in Shakespeare\u27s Romances

In this compact, yet comprehensive exploration of Shakespeare\u27s romances, Robert W. Uphaus suggests that the romances bring us to a realm of human and dramatic experience that is beyond tragedy. The inexorable movement of tragedy toward death and a final close is absorbed in romance by a further movement in which death can lead to renewed life, characters can experience a second time of joy and peace, and the audience\u27s conventional expectations about reality and literature are challenged and enlarged. In the late tragedies of King Lear and Antony and Cleopatra, Uphaus finds the tragic structure augmented by elements that will later contribute to the form of the romances. Turning then to the romances themselves, he sees these plays as forming a profession in which Pericles is a brilliant outline of the conventions of romance and Cymbeline is romance taken to its dramatic limits, in fact to the point of parody. Through his fresh and provocative readings of the plays we experience anew the delight of Shakespearean romance and glimpse the world of renewal at its heart. Robert W. Uphaus is professor of English at Michigan State University. He is also the author of The Impossible Observer: Reason and the Reader in Eighteenth-Century Prose.https://uknowledge.uky.edu/upk_english_language_and_literature_british_isles/1055/thumbnail.jp

The Impossible Observer: Reason and the Reader in Eighteenth-Century Prose

Rationality, objectivity, symmetry: were these really principles urged and exemplified by eighteenth-century English prose? In this persuasive study, Robert W. Uphaus argues that, on the contrary, many of the most important works of the period do not actually lead the reader into a new awareness of just how problematical, how unsusceptible to reason, both the world and our easy assumptions about it are. Uphaus discusses a broad range of writers—Swift, Defoe, Mandeyville, Richardson, Fielding, Sterne, Johnson, and Godwin—showing that beneath their variety lies a fundamentally similar challenge, addressed to the critical procedure which assumes that the exercise of reason is a sufficient tool for an understanding the appeal of imaginative literature. Robert W. Uphaus is associate professor of English at Michigan State University. Well informed, compact, and perspicuous . . . the book could serve as a vade mecum for a course in eighteenth-century prose. —South Atlantic Quarterly A convincing and always interesting view of how—and with what probable results—the writer of eighteenth-century prose went about forcing his reader to participate in his text. —Johnsonian Newsletterhttps://uknowledge.uky.edu/upk_english_language_and_literature_british_isles/1102/thumbnail.jp

Late Thrombectomy in Clinical Practice

Background and purpose!#!To provide real-world data on outcome and procedural factors of late thrombectomy patients.!##!Methods!#!We retrospectively analyzed patients from the multicenter German Stroke Registry. The primary endpoint was clinical outcome on the modified Rankin scale (mRS) at 3 months. Trial-eligible patients and the subgroups were compared to the ineligible group. Secondary analyses included multivariate logistic regression to identify predictors of good outcome (mRS ≤ 2).!##!Results!#!Of 1917 patients who underwent thrombectomy, 208 (11%) were treated within a time window ≥ 6-24 h and met the baseline trial criteria. Of these, 27 patients (13%) were eligible for DAWN and 39 (19%) for DEFUSE3 and 156 patients were not eligible for DAWN or DEFUSE3 (75%), mainly because there was no perfusion imaging (62%; n = 129). Good outcome was not significantly higher in trial-ineligible (27%) than in trial-eligible (20%) patients (p = 0.343). Patients with large trial-ineligible CT perfusion imaging (CTP) lesions had significantly more hemorrhagic complications (33%) as well as unfavorable outcomes.!##!Conclusion!#!In clinical practice, the high number of patients with a good clinical outcome after endovascular therapy ≥ 6-24 h as in DAWN/DEFUSE3 could not be achieved. Similar outcomes are seen in patients selected for EVT ≥ 6 h based on factors other than CTP. Patients triaged without CTP showed trends for shorter arrival to reperfusion times and higher rates of independence